Chemistry Letters

A practical method for the preparation of 4-nitrogen-substituted benzoic acids

T Shinozuka, A Nakao, K Saito, S Naito

文献索引：Shinozuka, Tsuyoshi; Nakao, Akira; Saito, Keiji; Naito, Satoru Chemistry Letters, 2006 , vol. 35, # 10 p. 1090 - 1091

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被引用次数: 2

摘要

An efficient and practical method for the preparation of 4-nitrogen-substituted benzoic acids is described. Our method consists of the aromatic substitution of 2, 2, 2, 4′- tetrafluoroacetophenone with amines, followed by haloform reaction to the benzoic acids. In this method, even though for the less nucleophilic 7-, 8-, and 9-membered amines 1 equiv. was used, corresponding benzoic acids were obtained in moderate to excellent yield. As ...