We previously have reported four possible binding conformations of dynorphin A (Dyn A) for the central κ opioid receptors, induced by the address sequence, using a molecular mechanics energy minimization approach. The lowest energy conformation was found to exhibit an α-helical conformation in the cyclized address sequence. It was suggested that an α-helical conformation in the cyclized address sequence or a helical conformation ...
[Kawasaki, Andrew M.; Knapp, Richard J.; Kramer, Thomas H.; Wire, William S.; Vasquez, Olga S.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1874 - 1879]
