Tetrahedron Letters

An efficient and convenient synthesis of 1, 2, 3-trisubstituted pyrroles via iodocyclization from ethyl acetoacetate

P Xu, K Huang, Z Liu, M Zhou, W Zeng

文献索引：Xu, Pengfei; Huang, Kunzhu; Liu, Zhiguo; Zhou, Ming; Zeng, Wenbin Tetrahedron Letters, 2013 , vol. 54, # 23 p. 2929 - 2933

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被引用次数: 8

摘要

A novel and efficient methodology for the synthesis of 1, 2, 3-trisubstituted pyrroles by one- pot two-step reaction has been developed. The iodocyclization of a series of β-enamino esters followed by dehydroiodination, led to the formation of corresponding pyrroles. This approach provides an easy access to a wide range of 1, 2, 3-trisubstituted pyrroles.