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Aromatic amino acid hydroxylase inhibitors. I. Halogenated phenylalanines

RE Counsell, P Desai, TD Smith, PS Chan…

文献索引:Counsell; Desai; Smith; Chan; Weinhold; Rethy; Burke Journal of medicinal chemistry, 1970 , vol. 13, # 6 p. 1040 - 1042

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被引用次数: 11

摘要

X comparisoii IJf all the riiig isonieric halopheriylalatiiiies inhibitors of pheriylalaiiirie aiid t. yro4tie hytiriisyl-: we revealed that optimal iiihihitioti was achieved with 3-iodopheiiylalaiiiIie. a-llethylation of the 3-halopheiiylalaniiies was fourid to eiihniice iiihibition of 1. yrosiiie hydroxylase, but have no effect, on phenylalaniiie hydroxylase. The implic. at, iotis of these findings are discussed.