Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1, 2-dihydropyrid-2-one …

MA Chowdhury, KRA Abdellatif, Y Dong, D Das…

文献索引：Chowdhury, Morshed A.; Abdellatif, Khaled R.A.; Dong, Ying; Das, Dipankar; Yu, Gang; Velazquez, Carlos A.; Suresh, Mavanur R.; Knaus, Edward E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6855 - 6861

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被引用次数: 17

摘要

A novel class of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1, 2-dihydropyrid-2-one pharmacophore attached to its C-4 or C-5 position was designed for evaluation as anti-inflammatory (AI) agents. Replacement of the 2, 4-difluorophenyl ring in diflunisal by the N-difluoromethyl-1, 2-dihydropyrid-2-one moiety provided compounds showing dual selective cyclooxygenase-2 (COX-2)/5- ...