Synthesis and Biological Activity of Novel 2-(. ALPHA.-Alkoxyimino) benzylpyridine Derivatives as K+ Channel Openers.

T MAEKAWA, S Yamamoto, Y Igata, S IKEDA…

文献索引：Maekawa, Tsuyoshi; Yamamoto, Satoshi; Igata, Yumiko; Ikeda, Shota; Watanabe, Toshifumi; Shiraishi, Mitsuru Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1994 - 2004

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被引用次数: 13

摘要

The search for novel K+ channel openers with a non-benzopyran skeleton, unlike cromakalim, led to the discovery of a new series of (Z)-2-(α-alkoxyimino) benzylpyridine derivatives. Synthesis was achieved by using a (Z)-dominant condensation reaction of benzoylpyridines with O-alkylhydroxylamines, followed by m-chloroperbenzoic acid (m- CPBA) oxidation. The compounds were tested for thier vasorelaxant activity in ...