Microwave-promoted automated synthesis of a coumarin library

M Katkevičs, A Kontijevskis, I Mutule, E Sūna

文献索引：Katkevics; Kontijevskis; Mutule; Suna Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 2 p. 151 - 159

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被引用次数: 24

摘要

Abstract A 30-membered library of coumarins has been synthesized in a microwave- assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin ...