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Ring transformation of pyrimidines to pyridines. Synthesis of 4??alkylaminopyridin??2??ones by alkaline hydrolysis of 6??(2??dimethylaminovinyl) uracils

…, T Asao, S Senda, Y Kitade, Y Maki

文献索引：Hirota, Kosaku; Abe, Yoshio; Asao, Tetsuji; Senda, Shigeo; Kitade, Yukio; Maki, Yoshifumi Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 985 - 990

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被引用次数: 9

摘要

Abstract Alkaline hydrolysis of 1, 3-disubstituted 6-(2-dimethylaminovinyl) uracils 2 induced a novel ring transformation giving 4-alkylaminopyridin-2-ones 3 via ring-opening and ring- closure processes. The 4-methylamino-3-nitropyridin-2-one (3a) thus obtained was employed for the synthesis of 3-deazahypoxanthine derivative 8. 4-Alkylamino-3- cyanopyridin-2-ones 11, ricinine analogs, were also prepared by the reaction of 4-chloro- ...

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1,3-dimethyl-6-(2-dimethylaminovinyl)-5-nitrouracil结构式

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