Journal of medicinal chemistry

Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity

YB Lee, MH Park, JE Folk

文献索引：Lee, Young Bok; Park, Myung Hee; Folk, J. E. Journal of Medicinal Chemistry, 1995 , vol. 38, # 16 p. 3053 - 3061

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被引用次数: 51

摘要

The enzyme deoxyhypusine synthase catalyzes the initial step in the posttranslational production of the amino acid hypusine [N'-(4-amino-2-hydroxybutyl) ly~ inel. l,~ This step, the transfer of the 4-aminobutyl moiety of the polyamine spermidine to the€-amino group of a lysine residue to form the deoxyhypusine [Ne-(4-aminobuty1) lysinel residue, occurs at a single position in only one cellular protein, the eukaryotic translation initiation factor 5A ( ...