Synthesis and activity of NAcSerAspLysPro analogs on cellular interactions between T-cell and erythrocytes in rosette formation

…, N Saez-Servent, J Plissonneau-Haumont…

文献索引：Thierry; Papet; Saez-Servent; Plissonneau-Haumont; Potier; Lenfant Journal of Medicinal Chemistry, 1990 ,  vol. 33,  # 8  p. 2122 - 2127

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被引用次数: 21

摘要

Analogues of NAcSerAspLysPro (AcSDKP), a natural regulator of hematopoiesis isolated from fetal calf bone mmow, were synthesized. The biological activity of these molecules were evaluated in vitro in the rosette assay, which measures the interaction between human Jurkat T-cells and sheep red blood cells. In this test, the tripeptide SerAspLys was the most efficient. Inhibitory activity was detected at the concentration M for the analogue and at ...