The Journal of Organic Chemistry

Antineoplastic agents. 166. Isolation, structure, and synthesis of combretastatin C-1

SB Singh, GR Pettit

文献索引：Singh, Sheo Bux; Pettit, George R. Journal of Organic Chemistry, 1989 ,  vol. 54,  # 17  p. 4105 - 4114

全文：HTML全文

被引用次数: 48

摘要

A new cell growth inhibitory (PS EDw 2.2 pg/mL) phenanthraquinone designated combretastatin C-1 (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-1 was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b-6b-2 and especially 5c-6c-2 proved to be quite practical.