Tetrahedron letters

Stereocontrolled Synthesis of the C (1)–C (11) Subunit of the Iejimalides

M Cottard, T Rein, P Helquist

文献索引：Mendlik, Matthew T.; Cottard, Muriel; Rein, Tobias; Helquist, Paul Tetrahedron Letters, 1997 ,  vol. 38,  # 36  p. 6375 - 6378

全文：HTML全文

被引用次数: 23

摘要

The gross structures of the iejimalides have been determined by NMR studies, but five of their six stereogenic centers remain unassigned. An anti relationship at C(22) and C(23) has been assigned tentatively, and the S configuration of C(32) has been established due to its presence in an easily characterized serine residue. [1] Thus C(4), C(9), C(17), C(22) and C(23) lack absolute stereochemical assignments. A total synthesis of the iejimalides must therefore permit ...