Abstract A synthesis of 1233A [(2E, 4E, 7R, 2′ R, 3′ R)-11-[3′-(hydroxymethyl)-4′-oxo- 2′-oxetanyl]-3, 5, 7-trimethyl-2, 4-undecadienoic acid (1a)] was achieved by employing (R)- 2-hydroxymethyl-3-butenyl acetate (2a) and (R)-citronellic acid (3) as chiral building blocks. The former was prepared by lipase-mediated asymmetric hydrolysis of the corresponding diacetate.
