Chemistry Letters

A Short and Efficient Total Synthesis of (.+-.)-Ascofuranone

Y Haga, T Tonoi, Y Anbiru, Y Takahashi, S Tamura…

文献索引：Haga, Yasushi; Tonoi, Takayuki; Anbiru, Yoshihide; Takahashi, Yuki; Tamura, Sayuri; Yamamoto, Masaichi; Ifuku, Shinsuke; Morimoto, Minoru; Saimoto, Hiroyuki Chemistry Letters, 2010 ,  vol. 39,  # 6  p. 622 - 623

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被引用次数: 1

摘要

Ascofuranone is a potent inhibitor of trypanosome alternative oxidase. A short and efficient total synthesis of (±)-ascofuranone was accomplished in only seven steps starting with geranyl acetate. The synthetic concept and methodology described in detail here provide a short and simple synthesis for ascofuranone and its derivatives.