Lithiated dimethylketene diisopropyl dithioacetal as a synthon of homoenolate dianion of isobutyric ester. An application to the synthesis of. ALPHA.- …
Lithium anion of dimethylketene diisopropyl dithioacetal reacted with various kinds of electrophiles to afford γ-substituted products with high regioselectivity. The utility of the lithiated ketene dithioacetal, a novel homoenolate dianion equivalent of isobutyric ester, was demonstrated in the synthesis of α-methylenelactones.
