Cobalt-mediated cyclization of amino acid derivatives. Application to the kainoids

JE Baldwin, CS Li

文献索引：Baldwin, Jack E.; Li, Chun-Sing Journal of the Chemical Society, Chemical Communications, 1987 ,  # 3  p. 166 - 168

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被引用次数: 38

摘要

An enantiospecific route to the kainoids has been developed based on cobalt-mediated cyclization of N-alken-2-yl amino acid derivatives. ... It is well established that alkyl-cobalt(II1) species can undergo homolysis (thermal or photochemical) as well as p-elimina- tionsl (Scheme 1). We now report the application of the homolysis and p-elimination sequence to the enantiospecific synthesis of substituted pyrrolidine structures found in the kainoid group of natural products ...