Tetrahedron letters

A highly efficient synthesis of γ-halo allylic alcohols and propargylic alcohols with high optical purity. Practical method for synthesis of the prostaglandin ω-chain

S Okamoto, T Shimazaki, Y Kobayashi, F Sato

文献索引：Okamoto, Sentaro; Shimazaki, Toshiyuki; Kobayashi, Yuichi; Sato, Fumie Tetrahedron Letters, 1987 ,  vol. 28,  # 18  p. 2033 - 2036

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被引用次数: 50

摘要

Summary: Kinetic resolution of y-trimethylsilyl allylic alcohols 2. by the Sharpless process combined with the reactivity of epoxysilyl or vlnylsilyl compounds affords a highly efficient method for preparation of optically pure y-halo secondary allylic alcohols of type l-4 and propargylic alcohols __ 14. thus providing a practical route to the prostaglandin w-chain.