Tetrahedron

A new approach to isoindolobenzazepines. A simple synthesis of lennoxamine

A Couture, E Deniau, P Grandclaudon, C Hoarau

文献索引：Couture, Axel; Deniau, Eric; Grandclaudon, Pierre; Hoarau, Christophe Tetrahedron, 2000 ,  vol. 56,  # 11  p. 1491 - 1499

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被引用次数: 68

摘要

Isoindolobenzazepine alkaloids, exemplified by lennoxamine 1 (Fig. 1), are a new class of alkaloids belonging to the aporhoedane series which have been extracted from Chilean Berberidaceae. 1 They are biogenetically related to protoberberines and usually ranked as isoquinoline alkaloids but their main structural feature is the presence of the distinctive isoindolo[1,2-b][3]benzazepine unit embedded in their skeleton. ... We now report an alternative, more efficient and ...