Journal of the American Chemical Society

The first nonenzymic stereospecific intramolecular reduction by an NADH-mimic containing a covalently bound carbonyl moiety

AI Meyers, JD Brown

文献索引：Meyers, A. I.; Brown, Jack D. Journal of the American Chemical Society, 1987 ,  vol. 109,  # 10  p. 3155 - 3156

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被引用次数: 43

摘要

We have recently described'the pure self-immolative chirality transfer between the stereochemically defined (S)-N-benzyl-3-(hydroxymethyl)-4-methyl-1, 4-dihydropyridine (1) and benzoylformic ester. The methyl mandelate (2) produced was found to be greater than 95% enantiomerically pure (corrected for the enantiomeric purity of 1) and possessed the S configuration. This