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Molecules

Synthesis of 4-methoxybenzoylhydrazones and evaluation of their antiglycation activity

…, H Naz, S Rasheed, NH Ismail, AA Rahman, S Yousuf…

文献索引:Taha, Muhammad; Naz, Humera; Rasheed, Saima; Ismail, Nor Hadiani; Rahman, Aqilah Abd; Yousuf, Sammer; Choudhary, Muhammad Iqbal Molecules, 2014 ,  vol. 19,  # 1  p. 1286 - 1301

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被引用次数: 18

摘要

Abstract: A series of 4-methoxybenzoylhydrazones 1–30 was synthesized and the structures of the synthetic derivatives elucidated by spectroscopic methods. The compounds showed a varying degree of antiglycation activity, with IC 50 values ranging between 216.52 and 748.71 µM, when compared to a rutin standard (IC 50= 294.46±1.50 µM). Compounds 1 (IC 50= 216.52±4.2 µM), 3 (IC 50= 289.58±2.64 µM), 6 (IC 50= 227.75±0.53 µM), 7 (IC 50= ...