Bioorganic & medicinal chemistry

A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors

NS Tulsi, AM Downey, CW Cairo

文献索引：Tulsi, Naresh S.; Downey, A. Michael; Cairo, Christopher W. Bioorganic and Medicinal Chemistry, 2010 ,  vol. 18,  # 24  p. 8679 - 8686

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被引用次数: 14

摘要

Protein tyrosine phosphatases (PTPs) are important therapeutic targets for medicinal chemists and biochemists. General strategies for the development of inhibitors of these enzymes are needed. Several modular strategies which rely on phosphotyrosine mimics are known for PTP inhibitors. Previous strategies include phosphonomethylphenylalanine (Pmp) derivatives which act as competitive inhibitors. Pmp amino acid derivatives have been ...