Tetrahedron

Synthesis of β-carboline-benzodiazepine hybrid molecules and their “amputated” analogues as novel ligands of the benzodiazepine receptor

C Dellouve-Courillon, G Dorey, G Poissonnet, X Doisy…

文献索引：Dellouve-Courillon; Dorey; Poissonnet; Doisy; Potier; Dodd Tetrahedron, 1990 , vol. 46, # 9 p. 3245 - 3266

被引用次数: 6

摘要

Two approaches to the synthesis of substituted β-carboline-benzodiazepine hybrid molecules, novel ligands of the benzodiazepine receptor of the central nervous system, were utilized. The first involved DDQ-promoted dehydrogenation of a tetrahydro-β-carboline- benzodiazepine derivative while the second method made use of a triflic anhydride- activated intramolecular condensation of the carboxylic acid functionality of a C-3 ...

Discovery of N-[(3 R)-1-Azabicyclo [2.2. 2] oct-3-yl] furo [...

[Wishka, Donn G.; Walker, Daniel P.; Yates, Karen M.; Reitz, Steven C.; Jia, Shaojuan; Myers, Jason K.; Olson, Kirk L.; Jacobsen, E. Jon; Wolfe, Mark L.; Groppi, Vincent E.; Hanchar, Alexander J.; Thornburgh, Bruce A.; Cortes-Burgos, Luz A.; Wong, Erik H. F.; Staton, Brian A.; Raub, Thomas J.; Higdon, Nicole R.; Wall, Theron M.; Hurst, Raymond S.; Walters, Rodney R.; Hoffmann, William E.; Hajos, Mihaly; Franklin, Stanley; Carey, Galen; Gold, Lisa H.; Cook, Karen K.; Sands, Steven B.; Zhao, Sabrina X.; Soglia, John R.; Kalgutkar, Amit S.; Arneric, Stephen P.; Rogers, Bruce N. Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4425 - 4436]