Heteroatom-directed metalation. Lithiation of N-propenylbenzamides and N-propenyl-O-toluamides. Novel routes to ortho-substituted primary benzamide derivatives …
LE Fisher, JM Muchowski, RD Clark
文献索引：Fisher, Lawrence E.; Muchowski, Joseph M.; Clark, Robin D. Journal of Organic Chemistry, 1992 , vol. 57, # 9 p. 2700 - 2705
The development of methods for the site-selective functionalization of aromatic systems continues to be an area of considerable interest in synthetic organic chemistry. One important tool for the predictable, direct transformation of an aryl compound into its ortho- substituted congener is the heteroatom-directed metalation reaction. 2 Of the many functional groups known to direct metalation to the ortho position, N, N- ...
