TDAE-assisted synthesis of new imidazo [2, 1-b] thiazole derivatives as anti-infectious agents

…, M Laget, T Terme, N Azas, P Vanelle

文献索引：Juspin, Thierry; Laget, Michele; Terme, Thierry; Azas, Nadine; Vanelle, Patrice European Journal of Medicinal Chemistry, 2010 , vol. 45, # 2 p. 840 - 845

全文：HTML全文

被引用次数: 37

摘要

A series of new imidazo [2, 1-b] thiazoles was prepared in moderate to good yields in a four step synthesis using the TDAE methodology from 6-chloromethyl-5-nitroimidazo [2, 1-b] thiazole and keto esters, ketomalonates and ketolactams. All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two Gram positive and two Gram negative ones) and four yeasts. Among these synthesized 5-nitroimidazo [2 ...