Intramolecular cyclization and cytotoxicities of some Mannich bases of styryl ketones

…, E Erciyas, GE Bigam, DL Kirkpatrick, MM Duke

文献索引：Dimmock; Erciyas; Bigam; Kirkpatrick; Duke European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 379 - 383

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被引用次数: 8

摘要

Abstract The extent of intramolecular cyclization in a series of Mannich bases derived from 2- arylidene-1, 3-diketones (series 5) was probably influenced by the steric and electronic properties of the different basic groups. Replacement of one of the keto groups in series 5 by hydrogen, methyl, carboethoxy and phenyl functions gave series 6 in which the intramolecular cyclization process was abolished. Evaluation of the compounds versus ...