This paper describes the synthesis and structure-activity relationships of a series of 2, 5- diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L- 652,731 were replaced with functional groups present in PAF and in the 'PAF- like'antagonists. Activity was generally retained or enhanced when one aryl ring in L- ...
