Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel μ opioid receptor ligands

…, ME Haggan, S Liras, S McLean, BE Segelstein

文献索引：Allen, Martin P.; Blake, James F.; Bryce, Dianne K.; Haggan, Mary E.; Liras, Spiros; McLean, Stafford; Segelstein, Barb E. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 523 - 526

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被引用次数: 12

摘要

The human opioid receptors μ, δ, and κ have been classified as members of the G protein coupled receptor family. 1, 2 and 3 The opioid receptors are abundantly present in the CNS and the periphery and mediate significant physiologic events that range from the perception of pain, mood and pleasure, to respiratory depression and regulation of the GI and immune systems. 4 The design and synthesis of potent and selective molecular probes that will define the biological ...