Stereospecific Palladium??Catalyzed Decarboxylative C (sp3) C (sp2) Coupling of 2, 5??Cyclohexadiene??1??carboxylic Acid Derivatives with Aryl Iodides
During the past few years we have shown that metalated cyclohexadienes are useful intermediates in asymmetric synthesis. Chiral cyclohexadienyl titanium derivatives, readily obtained by transmetalation of the corresponding lithiated species, react with various aldehydes with excellent stereoselectivities [Eq.(1)].[1] We later found that such desymmetrizations [2] can be run with Ag and Cu catalysts in combination with silylated ...
