Facile Regioselective Synthesis of Novel bis??Thiazole Derivatives and Their Antimicrobial Activity

NO Mahmoodi, J Parvizi, B Sharifzadeh…

文献索引：Mahmoodi, Nosrat O.; Parvizi, Jafar; Sharifzadeh, Bahman; Rassa, Mehdi Archiv der Pharmazie, 2013 , vol. 346, # 12 p. 860 - 864

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被引用次数: 14

摘要

The design and synthesis of several new bis-thiazoles 4a–h serving as bis-drugs in comparison with mono-heterocyclic analogs are described. These bis-drugs present superior medicinal and pharmacological activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with ...