Design, Synthesis, and Structure− Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1 H-pyrrol-2 (5 H)-one Analogues as Inhibitors of the …
…, HK Myrvang, PM Fischer, LV Dekker
文献索引：Reddy, Tummala R. K.; Li, Chan; Guo, Xiaoxia; Myrvang, Helene K.; Fischer, Peter M.; Dekker, Lodewijk V. Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2080 - 2094
S100 proteins are small adaptors that regulate the activity of partner proteins by virtue of direct protein interactions. Here, we describe the first small molecule blockers of the interaction between S100A10 and annexin A2. Molecular docking yielded candidate blockers that were screened for competition of the binding of an annexin A2 peptide to S100A10. Several inhibitory clusters were identified with some containing compounds ...
