Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid

ME El-Araby, RJ Bernacki, GM Makara, PJ Pera…

文献索引：El-Araby, Moustafa E.; Bernacki, Ralph J.; Makara, Gergely M.; Pera, Paula J.; Anderson, Wayne K. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2867 - 2879

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被引用次数: 19

摘要

Based on the promising activity of an indole-3-carboxamide derivative, a nonphenolic analog of mycophenolic acid (MPA), we report herein the synthesis of a compound containing two important features for the activity of MPA, the ring methoxy and methyl. The synthesis was accomplished using two strategies; a method dependent on stepwise building of the hexenoate side chain followed by the indolecarboxamide ring system, and a ...