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Progress in 5H [1] benzopyrano [4, 3-d] pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity

O Bruno, C Brullo, S Schenone, A Ranise, F Bondavalli…

文献索引：Bruno, Olga; Brullo, Chiara; Schenone, Silvia; Ranise, Angelo; Bondavalli, Francesco; Barocelli, Elisabetta; Tognolini, Massimiliano; Magnanini, Francesca; Ballabeni, Vigilio Farmaco, 2002 , vol. 57, # 9 p. 753 - 758

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被引用次数: 75

摘要

A series of 2-methoxy-5H [1] benzopyrano [4, 3-d] pyrimidin-5-amines were prepared and screened for their in vitro antiplatelet activity inducing the aggregation by ADP, arachidonic acid (AA) and collagen. In vivo experiments were performed in order to evaluate their antiphlogistic, analgesic and antipyretic activities. Title compounds showed antiplatelet activity in aggregation AA or collagen-induced, and a good analgesic activity without any ...