Tetrahedron

Synthesis of 9-substituted tetrahydrodiazepinopurines—asmarine A analogues

D Pappo, Y Kashman

文献索引：Pappo, Doron; Kashman, Yoel Tetrahedron, 2003 , vol. 59, # 34 p. 6493 - 6501

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被引用次数: 25

摘要

Asmarines are marine alkaloids, with a unique tetrahydro [1, 4] diazepino-[1, 2, 3-g, h] purine (THDAP) structure and interesting biological properties. Three synthetic approaches were employed for the preparation of the THDAP system. Several N-9, of the purine, protecting groups were investigated. 15N-Chemical shifts measured from 15NH HMBC experiments for several compounds, that demonstrate the influence of various structural features on the ...