2-(. beta.-Arylethylamino)-and 4-(. beta.-arylethylamino) quinazolines as phosphodiesterase inhibitors

…, TN Riley, IW Waters, ME Hamrick

文献索引：Millen, J.; Riley, T. N.; Waters, I. W.; Hamrick, M. E. Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 12 - 17

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被引用次数: 10

摘要

3 approximately equipotent with theophylline as an inhibitor of phosphodiesterase obtained from rat aorta. 14 The objective of the research described in this report is to investigate the effect of incorporating the aminoquinazoline heterocycle and various@-arylethanolamine moieties into a single molecule. A number of P-arylethanolamine derivatives, including the saligenin derivative albuterol (4) and the resorcinol derivative terbutaline (5), are ...