Molecules

Arylsulfonylamino-Benzanilides as Inhibitors of the Apical Sodium-Dependent Bile Salt Transporter (SLC10A2)

…, XG Bai, JX Wang, CL Xu, SY Cai, RG Shao, YC Wang

文献索引：Liu, Hong-Tao; He, Hong-Wei; Bai, Xiao-Guang; Wang, Ju-Xian; Xu, Chang-Liang; Cai, Shi-Ying; Shao, Rong-Guang; Wang, Yu-Cheng Molecules, 2013 , vol. 18, # 6 p. 6883 - 6897

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被引用次数: 2

摘要

Abstract: The apical sodium-dependent bile salt transporter (ASBT) plays a pivotal role in maintaining bile acid homeostasis. Inhibition of ASBT would reduce bile acid pool size and lower cholesterol levels. In this report, a series of novel arylsulfonylaminobenzanilides were designed and synthesized as potential inhibitors of ASBT. Most of them demonstrated great potency against ASBT's bile acid transport activity. In particular, compound 5g 2 inhibited ...