Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products

H Hoang, DV LaBarbera, KA Mohammed…

文献索引：Hoang, Hung; LaBarbera, Daniel V.; Mohammed, Kaleem A.; Ireland, Chris M.; Skibo, Edward B. Journal of Medicinal Chemistry, 2007 , vol. 50, # 19 p. 4561 - 4571

全文：HTML全文

被引用次数: 29

摘要

This report describes the synthesis and biological activity of imidazoquinoxalines, benzimidazole-based analogues of indole-based pyrroloiminoquinone marine natural products. Our analogues consist of series 1, which possesses the ethylene tether and extended amidine feature found in the pyrroloiminoquinone natural products, and series 2, which also has the ethylene tether but with an electrostatically stabilized iminoquinone ...