Sildenafil (Viagra TM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

NK Terrett, AS Bell, D Brown, P Ellis

文献索引：Terrett, Nicholas K.; Bell, Andrew S.; Brown, David; Ellis, Peter Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1819 - 1824

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被引用次数: 499

摘要

5-(2′-Alkoxyphenyl) pyrazolo [4, 3-d] pyrimidin-7-ones, and in particular our preferred compound, sildenafil (VIAGRATM), discovered through a rational drug design programme, are potent and selective inhibitors of the type 5 cGMP phosphodiesterase from both rabbit platelets and human corpus cavernosum. Sildenafil is currently in the clinic for the oral treatment of male erectile dysfunction.