Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline
LJC Bolchoz, RA Budinsky, DC McMillan…
文献索引：Bolchoz, Laura J. C.; Budinsky, Robert A.; Mcmillan, David C.; Jollow, David J. Journal of Pharmacology and Experimental Therapeutics, 2001 , vol. 297, # 2 p. 509 - 515
Abstract Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-limiting side effects of primaquine therapy that limit its efficacy. These hemotoxicities are thought to be mediated by metabolites; however, the identity of the toxic species has remained unclear. SinceN-hydroxy metabolites are known to mediate the ...
