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Improved Synthesis of 1 H-Pyrazole-4-carbaldehyde

IV Taydakov, SS Krasnoselskiy…

文献索引:Taydakov, Ilya V.; Krasnoselskiy, Sergey S.; Dutova, Tatiana Y. Synthetic Communications, 2011 , vol. 41, # 16 p. 2430 - 2434

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被引用次数: 8

摘要

Abstract A simple and convenient two-step method for the synthesis of the title compound 1 was developed using N-protected 4-pyrazolilmagnesium bromide 9 as a key intermediate. Laborious procedures for purification or isolation of target compound are not required, therefore, up to 20 g of 1 could be obtained in a single run.