Antiinflammatory and analgesic diastereoisomeric derivatives of indan-5-acetic acid

JM Teulon, JC Cognacq, F Hertz, JM Lwoff…

文献索引：Teulon,J.M. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 901 - 905

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被引用次数: 12

摘要

Various 2-alkyl-a-methyl-and 2-alkylindan-5-acetic acids have been prepared. The acids, which can exist in two diastereoisomeric forms that cannot be separated by crystallization or chromatography, can be analyzed in their mixture by NMR in the presence of Eu (dpm),. It has been possible to reconstitute the two pure racemic 2-isopropyl-a-methylindan-5-acetic acids from their enantiomers obtained after resolution of the mixtures through salts with ...