Enhancing the enantioselectivity of CALB by substrate imprinting: A combined experimental and molecular dynamics simulation model study

L Chaput, Z Marton, P Pineau, L Domon, V Tran…

文献索引：Chaput; Marton; Pineau; Domon; Tran; Graber Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 55 - 61

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被引用次数: 5

摘要

Kinetic resolution of pentan-2-ol by CALB catalyzed enantioselective transesterification, with various alkylpropanoate acyl donors, was studied in a solid-gas reactor. Results show that the leaving alkoxy group influences the enantiomeric ratio of the reaction. Resolution of pentan-2-ol with methyl propanoate gives an enantiomeric ratio of 62. Esters with longer linear alkyl chains, from ethyl to pentyl propanoate give higher enantiomeric ratios, ...