Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human β3-adrenergic receptor agonists with good oral bioavailability. Part I

M Imanishi, Y Tomishima, S Itou…

文献索引：Petit,L.; Sonnier,M. Bulletin de la Societe Chimique de France, 1974 , p. 477 - 478

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被引用次数: 33

摘要

... 2,6-lutidine, CH 2 Cl 2 , −70°C; (d) Fe (powder), NH 4 Cl, EtOH, reflux; (e) 35% HCHO, NaBH(OAc) 3 , AcOH, CH 2 Cl 2 ; (f) PhCHO, p-TsOH, toluene ... NaIO 4 , NH 4 OAc, acetone, H 2 O; (d) NaH, alcohol or thiol, N,N-DMF, then MeI, K 2 CO 3 , N,N-DMF; (e) i-BuMgCl (2 M in THF ...