The total synthesis of cephalosporin C1

RB Woodward, K Heusler, J Gosteli…

文献索引：Woodward,R.B. et al. Journal of the American Chemical Society, 1966 , vol. 88, p. 852 - 853

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被引用次数: 376

摘要

XV [aIz0~ $14"(c 0.95, CHCl3), which was easily separated by chromatography on silica gel, and reduced by zinc dust in 90% aqueous acetic acid at room temperature to cephalothin (11), mp 160-160.5",[a]"~ $50"(c 1.03, CH3CN), whose properties were identical in all respects with those of material prepared from natural cephalosporin C. 6