Tetrahedron Letters

Stereoselective synthesis of C-6 hydroxy tricyclic sulfone as a γ-secretase inhibitor

J Su, H Tang, BA McKittrick

文献索引：Su, Jing; Tang, Haiqun; McKittrick, Brian A. Tetrahedron Letters, 2011 , vol. 52, # 26 p. 3382 - 3385

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被引用次数: 7

摘要

One hallmark of Alzheimer's disease (AD) pathology is the presence of extracellular plaques composed of β-amyloid peptides (Aβ), a 38-42 amino acid fragment from amyloid precursor protein (APP) by the sequential action of β-site APP cleaving enzyme (BACE) and γ-secretase. The accumulation of Aβ42, the longer form Aβ, is believed to lead to aggregation, plaque deposition and neurotoxicity. Therefore, a BACE or γ-secretase inhibitor may serve as a treatment for AD. ...