Paullones 1 are a series of structures from 7,12-dihydroindolo[3,2-d]benzazepin-6(5H)-ones , 2 which constitute a class of CDK inhibitors. 3 These cyclin-dependent kinases 2 (CDKs) are a family of serine–threonine kinases that play a major role in cell cycle division. In a wide variety of human tumors and tumor cell lines, CDK-related mechanisms are deregulated. 4 Synthetic CDK-inhibitors have been studied as potential candidates for treating neoplastic ...
