N-{[(6-Substituted-1, 3-benzothiazole-2-yl) amino] carbonothioyl}-2/4-substituted benzamides: Synthesis and pharmacological evaluation

A Rana, N Siddiqui, SA Khan, SE Haque…

文献索引：Rana, Arpana; Siddiqui, Nadeem; Khan, Suroor A.; Ehtaishamul Haque, Syed; Bhat, Mashooq A. European Journal of Medicinal Chemistry, 2008 , vol. 43, # 5 p. 1114 - 1122

全文：HTML全文

被引用次数: 97

摘要

A series of 1, 3-benzothiazol-2-yl benzamides (11–30) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity, CNS depressant study and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES and scPTZ screen and showed the decrease in the immobility time. None of the compounds had shown neurotoxicity or ...