Exploitation of subtilisin BPN'as catalyst for the synthesis of peptides containing noncoded amino acids, peptide mimetics and peptide conjugates
WJ Moree, P Sears, K Kawashiro, K Witte…
文献索引：Moree, Wilna J.; Sears, Pamela; Kawashiro, Katsuhiro; Witte, Krista; Wong, Chi-Huey Journal of the American Chemical Society, 1997 , vol. 119, # 17 p. 3942 - 3947
The ability of the serine protease subtilisin BPN'to catalyze peptide bond formation between fragments containing noncoded amino acids, peptide mimetics, and peptide conjugates in a kinetic approach was explored. It was found that the enzyme accepts numerous of these types of compounds both as acyl donor and acyl acceptor. The results together with specificity studies reported by others provide an active site model as a guideline in the ...
