Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases

T Wang, ML Lamb, DA Scott, H Wang…

文献索引：Creemer, Lawrence C.; Bargar, Thomas M.; Wagner, Eugene R. Synthetic Communications, 1988 , vol. 18, # 10 p. 1103 - 1110

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被引用次数: 51

摘要

... Volume: Page: ... The general synthetic sequence for the 2,4-disubstituted pyrimidines is shown in Scheme 1. 2,4-Dichloropyrimidines 6 were reacted with ... a Reagents and conditions: (a)CH 3 CN, NaH, dioxane; (b)H 2 NNH 2 ; (c) R 9 OH, DIAD, PPH 3 , CH 2 Cl 2 ...