Journal of heterocyclic chemistry

Syntheses of 8??aminoimidazo [4′, 5′: 5, 6] pyrido [2, 3??d] pyrimiciines: Linear tricyclic analogs of adenine

PA Harris, W Pendergast

文献索引：Harris, Philip A.; Pendergast, William Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 2 p. 319 - 322

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被引用次数: 7

摘要

Abstract The syntheses of 8-aminoimidazo [4′, 5′: 5, 6] pyrido [2, 3-d] pyrimidines (7), stretched-out versions of the naturally occuring nucleoside base adenine, are reported. Their preparation involves conversion of purine into 5-arninoimidazo [4, 5-b] pyrimidine-6- carbonitrile (1) by reaction with malononitrile, followed by construction of the pyrimidine ring in two steps via the ethoxymethylene derivative 3. 8-Azapurine can be converted to 8- ...