… and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1, 4-diazepin-6-yl) pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 …
A structurally original series of N-(1-ethyl-4-methylhexahydro-1, 4-diazepin-6-yl) pyridine-3- carboxamides derived from the corresponding benzamide 5 were prepared and evaluated for their binding affinity for the dopamine D2 and serotonin 5-HT3 receptors using rat striatum and rat cortical membrane, respectively. Many of the synthesized pyridine-3- carboxamides exhibited nanomolar binding affinity for the serotonin 5-HT3 receptor along ...
